ANODYNE is a ‘Greek’ word for chemicals used for purification of water. At Anodyne we have only one main objective – to provide problem specific solutions and thereby reducing industrial waste of resource in the form of water. WELCOME TO ANODYNE, INC. We ourselves on dynamic customer service and quality medical products. Established in 1987 as a specialty dealer of medical products and supplies, we have since expanded to one of the most complete providers of durable medical equipment and services in the Midwest.

Study selectionProspective or retrospective experimental studies or case histories that assessed anodyne therapy system or monochromatic infrared energy at 890nm wavelength in patients with diabetic peripheral neuropathy were eligible for inclusion.Patients in included studies used either clinical or home anodyne therapy system devices. Most studies focused on patients who had either type I or II diabetes mellitus. Most studies required that patients had some kind of sensory impairment at the outset of the study; Semmes-Weinstein monofilaments was the most frequently used technique for evaluating sensory impairment levels. Where stated, mean duration of disease ranged from two to 16 years.

Few studies reported whether the onset of disease was genetic or acquired. Average age ranged from 60.4 to 78 years.The authors stated neither how studies were selected for the review nor how many reviewers performed the selection.

CRD commentaryThis review addressed a clear objective supported by defined inclusion criteria for patients, study design and interventions, but not for outcomes. Relevant sources were searched for English-language studies, so there was a possibility of language bias. Some studies may have been missed as the authors did not undertake an extensive search for unpublished studies. It was unclear whether appropriate steps were taken to reduce reviewer error and bias in the selection of studies and data extraction. Study quality was not formally assessed and so the reliability of the included studies was unclear. Some quality criteria were discussed within the review and (as acknowledged by the authors) shortcomings among the included studies included poor study designs, small sample sizes (most studies had. Implications of the review for practice and researchThe authors did not state any implications for practice.Research: The authors stated that large well-designed placebo-controlled RCTs were required to determine the effectiveness of anodyne therapy system for treating patients with diabetic peripheral neuropathy.

Such studies should provide more information regarding patient disease or condition characteristics, as well as improved standardisation of pre-treatment sensory impairment, balance and fall risk measurements and improved control of concomitant therapies.

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